Two leagues with the same number of teams can produce completely different boards. These are the settings that move player values the most, in order.
Adding a second quarterback slot moves the top twelve passers up one to two full rounds, because a startable QB is suddenly a scarce asset instead of a commodity. If your league is Superflex and your board is not, every quarterback ranking you are looking at is wrong.
Full PPR lifts high-volume slot receivers and pass-catching backs over touchdown-dependent players. Half PPR compresses the gap; standard scoring pushes early-down backs back into the first round conversation.
A league that starts three receivers and a flex drains the WR pool much faster than one that starts two. Replacement level — the last startable player at each position — is derived from roster slots times teams, and every value on the board keys off it.
In a 10-team league the waiver wire is a real safety net, so you can draft upside. In a 14-team league there is no safety net, so floor and workload security matter more.