The draft room reads your league's scoring, roster slots and pick order, then re-prices every remaining player after each selection. Below is the same process written out, so you can follow it whether or not the board is synced.
ADP tells you when a player goes, not what he is worth to your roster. Value over replacement compares each player to the last starter you could get at that position in your league size. In a 12-team half-PPR league the RB gap between RB12 and RB30 is roughly four points a week, while the WR gap over the same span is closer to two. That is why an RB run costs you more than a WR run, and why the room pushes backs up when three go off the board in a row.
A positional run is three or more picks at one position inside a single turn of the snake. Runs strip the tier you were planning on and simultaneously discount the position nobody is taking. The disciplined move is to let the run finish, take the best player at the ignored position, and come back to the run position at the tier break rather than at the top of the next tier.
At the turn you pick twice in a row, so treat picks 2.01 and 2.12 style pairs as one decision. Look at how many players from your target tier are likely to survive the wheel: if four remain and eight picks happen before your next turn, one is likely gone but not all four. Take the scarcer position first and the deeper one on the way back.
Late-round picks should either back up a starter whose workload would transfer cleanly, or take a shot at a player with standalone weekly usage. Handcuffing your own RB1 protects the pick you spent the most on; drafting a fourth quarterback does not protect anything.